Wednesday, December 14, 2011

Health Expenditures in the US: Are We Not Spending Enough?

According the Elizabeth Bradley, a Professor of Health Policy and Administration at Yale, the answer is no. As she and Lauren Taylor point out in a recent New York Times editorial:

We studied 10 years’ worth of data and found that if you counted the combined investment in health care and social services, the United States no longer spent the most money — far from it. In 2005, for example, the United States devoted only 29 percent of gross domestic product to health and social services combined, while countries like Sweden, France, the Netherlands, Belgium and Denmark dedicated 33 percent to 38 percent of their G.D.P. to the combination. We came in 10th.

Bradley and Taylor put forth the argument that the things that make people healthy go beyond what we typically think of as health care. That is, access to employment, good housing, food security, and educational institutions all contribute to population health. I don't think this is a revolutionary thought.

But what is revolutionary is that they authors imply that the answer to our central question for US health care - "Do we get what we pay for?" - might not be the "no" we've always assumed, but a "yes." We just aren't spending enough, at least not on the proximal things that really matter. I don't think that it is that simple - it's hard to know what portion of social service spending actually improves health. But the discourse does need to move in this direction.

Furthermore, another neat aspect of this piece is that Bradley and Taylor's contention doesn't just apply to the macro-level health policy sphere. Imagine a primary care system that takes into account the socioeconomic realities of patients and creates interventions that use these insights to better provide care. A developing country example: subsidizing the transportation fees for HIV/AIDS patients who would otherwise find this to be a barrier and be unable to seek much needed health care. This sort of intervention may be equally important to any medications or lab tests in advancing the health of these patients. I'll talk more about this sort of "economic hotspotting" in a later post.

Tuesday, December 6, 2011

Great Harvard Med Class Show Parody

As an intern, I get to work side by side with Harvard medical students. I have to say that they have all been very, very good in terms of their clinical knowledge and ability to efficiently get things done. No wonder I got rejected when I applied.

It turns out that Harvard med students are pretty funny, too. Check out this great parody of medical students' experiences while on their third year clinical rotations by members of the Class of 2014. I'm sure you'll recognize the Saturday Night Live short this is based on. (HT: the awesome and hilarious Camila Fabersunne).

Sunday, December 4, 2011

Male Circumcision, HIV/AIDS and the "Real World"

This past week, PLoS Medicine put forth multi-piece expose (start with this lead/summary article) on medical male circumcision, its cost-effectiveness in combating HIV/AIDS and methods and challenges to scaling up this practice in Sub-Saharan Africa, where the epidemic is at its worst. The upshot of this series of papers was covered in a recent Scientific American piece (which quotes yours truly). To summarize, the argument is that medical male circumcision works (as demonstrated in three large randomized clinical trials, all conducted in Africa) and is cost-effective. Indeed, it may even be cost-saving, with high upfront costs that are easily recovered over a 10 year period. Challenges to scale-up include finding health care workers to carry out circumcisions (in a way that doesn't crowd-out provision of other important health care services), getting people to adopt the practice in a respectful, non-coercive yet effective way, especially in areas where there are strong traditional norms over circumcision, and dealing with any risk compensating behavior (if circumcised individuals think circumcision is protective, they may be more likely to engage in riskier sexual behaviors than they otherwise would - more on this in a later post).

Circumcision is one of those topics that seems to always bring with it a vociferous debate. Those opposed to the practice make their stance known quite vehemently. In my opinion, much of what is being spouted against medical male circumcision as a tool for HIV prevention is based on an incomplete understanding of the available evidence and already strong negative priors against the practice that are almost impossible to shift (for example, see this clip or refer to any of the comments to the aforementioned Scientific American article).

However, I think there is one oft-cited argument against medical male circumcision that is worth discussing further. In particular, opponents point to evidence from a 2009 UNAIDS study that uses recent survey data from 18 African countries and concludes that "there appears no clear pattern of association between male circumcision and HIV prevalence—in 8 of 18 countries with data, HIV prevalence is lower among circumcised men, while in the remaining 10 countries it is higher." This is contrast to the large randomized clinical trials mentioned above which show that circumcision reduces HIV rates by greater than 50%. The fact that the clinical trial results are not borne out in the sample survey data, opponents argue, means that circumcision does not work in "real world settings."

In a recent study, Brendan Maughan-Brown, Nicoli Nattrass, Jeremy Seekings, Alan Whiteside and I offer a different explanation for this differential set of findings. It has to do with the fact that the UNAIDS study looks at population that were circumcised in a multitude of settings (clinics, traditional healers) whereas the clinical trials focus on medical circumcision only. In practice, there great deal of heterogeneity in traditionally circumcising populations: some people do not have all of their foreskin removed, and others are circumcised several years after their peers. In our study population of blacks living in the Cape Town metro area, when we don't account for this heterogeneity, we find only a weak negative effect of circumcision on HIV positivity. However, once we "unpack" circumcision, we find that the practice actually has a strong negative association with the probability of testing HIV positive, provided it is done earlier and that there is complete removal of the foreskin.

These results suggest that the UNAIDS results may simply be due to measurement error. In a traditional setting, a circumcision is not a circumcision is not a circumcision. Treating every circumcised person the same introduces measurement error, and statistically it is well known that this would deflate the estimates of the impacts of the practice towards zero. So, the differential results between the UNAIDS findings and the randomized clinical trial findings is not that circumcision doesn't work in the real world. Rather, it is that we really need to understand better the heterogeneity in male circumcision and what can be done to ensure better outcomes for everyone involved.